Melira, the Living Cure + Tainted Strike Combos

Combo 1 with Skirk Fire Marshal

Steps

1. Cast Tainted Strike by paying {B}, giving Skirk Fire Marshal +1/+0 and infect until end of turn.
2. Activate Skirk Fire Marshal by tapping five Goblins you control, putting ten -1/-1 counters on each creature and giving each opponent ten poison counters, and you one poison counter.
3. Each opponent loses the game due to having ten poison counters.